宿主细胞感染支原体后的“宿命”

doi:10.11843/j.issn.0366-6964.2018.03.001

摘要/Abstract

摘要：

支原体（Mycoplasma）是介于细菌与病毒之间的一类原核微生物，无细胞壁，依靠细胞膜维持其个体形态和多种生理功能。临床上，支原体可引起动物和人类多种疾病，严重影响畜牧业的发展，威胁人类健康，但是目前针对支原体疾病的抗生素治疗效果不佳、疫苗有效性较差，且缺乏较为敏感的诊断工具，加之支原体个体微小、生长缓慢，暂缺乏有效的研究手段，其感染宿主细胞的分子机制仍不清楚，因此，至今支原体引起的疾病很难预防和控制。随着人们对支原体感染宿主细胞机制愈发关注，并取得了一些进展，本文就支原体感染后诱导宿主细胞的凋亡、自噬、癌变等方面进行概述，以期对支原体致病机制的研究提供帮助。

Abstract:

Mycoplasma is one of the smallest prokaryotic microorganisms without cell wall, and it relies on the cell membrane to maintain individual morphology and physiological functions. Mycoplasma is a pathogenic microorganism, which could cause variety of diseases for both human and animals. It is seriously affected the development of animal husbandry and threatened human health. Diseases caused by Mycoplasma are very difficult to prevent and control due to lack of the sensitive diagnostic tools, the clinical efficacy of antibiotics and vaccine. For further development, it is urgently necessary to undertake an in-depth study of its unclear pathogenesis. As much attention were paid on Mycoplasma infection and some progress were achieved, this article summarizes the mycoplasma-induced host cell apoptosis, autophagy and carcinogenic in order to contribute to Mycoplasma pathogenesis research.

中图分类号:

S852.62

吴习习, 罗海霞, 郝秀静, 马春骥, 李敏. 宿主细胞感染支原体后的“宿命”[J]. 畜牧兽医学报, 2018, 49(3): 459-465.

WU Xi-xi, LUO Hai-xia, HAO Xiu-jing, MA Chun-ji, LI Min. The Fate of Cell Infected With Mycoplasma[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(3): 459-465.

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参考文献

[1] 吴移谋, 叶元康. 支原体学[M]. 2版. 北京:人民卫生出版社, 2008:1.
WU Y M, YE Y K. Mycoplasmology[M]. 2nd ed. Beijing:People's Medical Publishing House, 2008:1. (in Chinese)
[2] TOUATI A, CAZANAVE C, BÉBÉAR C. Strain typing of Mycoplasma pneumoniae and its value in epidemiology[J]. Curr Pediatr Rev, 2013, 9(4):334-342.
[3] BANSAL P, ADEGBOYE D S, ROSENBUSCH R F. Immune responses to the capsular polysaccharide of Mycoplasma dispar in calves and mice[J]. Comp Immunol Microbiol Infect Dis, 1995, 18(4):259-268.
[4] 刘紫玲, 游晓星, 彭志平, 等. 肺炎支原体荚膜多糖与DC-SIGN结合并促进IL-10的分泌[J]. 细胞与分子免疫学杂志, 2013, 29(1):10-13.
LIU Z L, YOU X X, PENG Z P, et al. Mycoplasma pneumoniae capsular polysaccharides bind to DC-SIGN and promote the secretion of IL-10[J]. Chinese Journal of Cellular and Molecular Immunology, 2013, 29(1):10-13. (in Chinese)
[5] NIANG M, ROSENBUSCH R F, ANDREWS J J, et al. Demonstration of a capsule on Mycoplasma ovipneumoniae[J]. Am J Vet Res, 1998, 59(5):557-562.
[6] JIANG Z J, SONG F Y, LI Y N, et al. Capsular polysaccharide is a main component of Mycoplasma ovipneumoniae in the pathogen-induced Toll-like receptor-mediated inflammatory responses in sheep airway epithelial cells[J]. Mediators Inflamm, 2017, 2017:9891673.
[7] JIANG Z J, SONG F Y, LI Y N, et al. Capsular polysaccharide of Mycoplasma ovipneumoniae induces sheep airway epithelial cell apoptosis via ROS-dependent JNK/P38 MAPK pathways[J]. Oxid Med Cell Longev, 2017, 2017:6175841.
[8] 王素果. 支原体脂质相关膜蛋白致病机制的研究进展[J]. 微生物学免疫学进展, 2016, 44(4):42-47.
WANG S G. Pathogenic mechanisms on Mycoplasma lipid-associated membrane proteins[J]. Progress in Microbiology and Immunology, 2016, 44(4):42-47. (in Chinese)
[9] ARCHER D B. The structure and functions of the Mycoplasma membrane[J]. Int Rev Cytol, 1981, 69:1-44.
[10] BAI F F, NI B, LIU M J, et al. Mycoplasma hyopneumoniae-derived lipid-associated membrane proteins induce inflammation and apoptosis in porcine peripheral blood mononuclear cells in vitro[J]. Vet Microbiol, 2015, 175(1):58-67.
[11] 汪洋. 鸡毒支原体生物被膜相关基因筛选及其LAMPs诱导细胞凋亡的研究[D]. 北京:中国农业科学院, 2017.
WANG Y. Screening of biofilm-forming mutants and effect of LAMPs on apoptosis of chicken embryo fibroblast for Mycoplasma gallisepticum[D]. Beijing:Chinese Academy of Agricultural Sciences, 2017. (in Chinese)
[12] HE J, WANG S P, ZENG Y H, et al. Binding of CD14 to Mycoplasma genitalium-derived lipid-associated membrane proteins upregulates TNF-α[J]. Inflammation, 2014, 37(2):322-330.
[13] 欧广利. 核因子Nrf2负向调节肺炎支原体LAMPs诱导人THP-1细胞产生炎症物质[D]. 衡阳:南华大学, 2015.
OU G L. Nuclear factor Nrf2 negatively regulated inflammatory substances production induced by lipid-associated membrane proteins derived from Mycoplasma pneumoniae in human monocyte cell line THP-1 cells[D]. Hengyang:University of South China, 2015. (in Chinese)
[14] WANG Y, LIU S L, LI Y, et al. Mycoplasma bovis-derived lipid-associated membrane proteins activate IL-1β production through the NF-κB pathway via Toll-like receptor 2 and MyD88[J]. Dev Comp Immunol, 2016, 55:111-118.
[15] WANG Y, WANG Q, LI Y, et al. Mmm-derived lipid-associated membrane proteins activate IL-1β production through the NF-κB pathway via TLR2, MyD88, and IRAK4[J]. Sci Rep, 2017, 7(1):4349.
[16] WELLS P G, MILLER-PINSLER L, BHATIA S, et al. Reactive Oxygen Species (ROS) formation, oxidative DNA damage and repair in teratogenesis[J]. Birth Defects Res A, 2015, 103(5):359-359.
[17] KUWANO K, HAGIMOTO N, MAEYAMA T, et al. Mitochondria-mediated apoptosis of lung epithelial cells in idiopathic interstitial pneumonias[J]. Lab Invest, 2002, 82(12):1695-1706.
[18] LI Y N, JIANG Z J, XUE D, et al. Mycoplasma ovipneumoniae induces sheep airway epithelial cell apoptosis through an ERK signalling-mediated mitochondria pathway[J]. BMC Microbiol, 2016, 16:222.
[19] MCCUBREY J A, LAHAIR M M, FRANKLIN R A. Reactive oxygen species-induced activation of the map kinase signaling pathways[J]. Antioxid Redox Signal, 2006, 8(9-10):1775-1789.
[20] XUE D, LI Y N, JIANG Z J, et al. A ROS-dependent and caspase-3-mediated apoptosis in sheep bronchial epithelial cells in response to Mycoplasma ovipneumoniae infections[J]. Vet Immunol Immunopathol, 2017, 187:55-63.
[21] INOSHITA S, TAKEDA K, HATAI T, et al. Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress[J]. J Biol Chem, 2002, 277(46):43730-43734.
[22] SON Y, CHEONG Y K, KIM N H, et al. Mitogen-activated protein kinases and reactive oxygen species:how can ROS activate MAPK pathways?[J]. J Signal Transduct, 2011, 2011:792639.
[23] NAKAJIMA S, KITAMURA M. Bidirectional regulation of NF-κB by reactive oxygen species:a role of unfolded protein response[J]. Free Radic Biol Med, 2013, 65:162-174.
[24] MORGAN M J, LIU Z G. Crosstalk of reactive oxygen species and NF-κB signaling[J]. Cell Res, 2011, 21(1):103-115.
[25] PAVEL M, RUBINSZTEIN D C. Mammalian autophagy and the plasma membrane[J]. FEBS J, 2017, 284(5):672-679.
[26] SHIMIZU T. Pathogenic factors of Mycoplasma[J]. Nihon Saikingaku Zasshi, 2015, 70(4):369-374.
[27] LU Z Y, XUE D Y, CHEN Y, et al. TLR2 mediates autophagy through ERK signaling pathway in Mycoplasma gallisepticum-infected RAW264.7 cells[J]. Mol Immunol, 2017, 87:161-170.
[28] SHIMIZU T, KIMURA Y, KIDA Y, et al. Cytadherence of Mycoplasma pneumoniae induces inflammatory responses through autophagy and toll-like receptor 4[J]. Infect Immun, 2014, 82(7):3076-3086.
[29] SHIMIZU T. Inflammation-inducing factors of Mycoplasma pneumoniae[J]. Front Microbiol, 2016, 7:414.
[30] 孙远航. 绵羊肺炎支原体诱导肺脏上皮细胞自噬的初步研究[D]. 银川:宁夏大学, 2016.
SUN Y H. Preliminary study of Autophagy in lung epithelial cells induced by M. ovipneumoniae infection[D]. Yinchuan:Ningxia University, 2016. (in Chinese)
[31] HU X, YU J, ZHOU X, et al. Synergism between upregulation of Rab7 and inhibition of autophagic degradation caused by mycoplasma facilitates intracellular Mycoplasma infection[J]. Mol Med Rep, 2014, 9(3):793-800.
[32] NISHIUMI F, OGAWA M, NAKURA Y, et al. Intracellular fate of Ureaplasma parvum entrapped by host cellular autophagy[J]. Microbiologyopen, 2017, 6(3):e441.
[33] 张必雄,熊祺琰,王佳,等. 猪鼻支原体表面可变脂蛋白vlpA黏附宿主细胞功能研究[J]. 畜牧兽医学报, 2016, 47(9):1897-1904.
ZHANG B X,XIONG Q Y,WANG J,et al. The function of the variable lipoprotein A of Mycoplasma hyorhinis in adherence to host cell[J]. Acta Veterinaria et Zootechnica Sinica, 2016, 47(9):1897-1904. (in Chinese)
[34] WANG R Y H, SHIH J W K, WEISS S H, et al. Mycoplasma penetrans infection in male homosexuals with AIDS:high seroprevalence and association with Kaposi's sarcoma[J]. Clin Infect Dis, 1993, 17(4):724-729.
[35] BARYKOVA Y A, LOGUNOV D Y, SHMAROV M M, et al. Association of Mycoplasma hominis infection with prostate cancer[J]. Oncotarget, 2011, 2(4):289-297.
[36] HRBACEK J, URBAN M, HAMSIKOVA E, et al. Serum antibodies against genitourinary infectious agents in prostate cancer and benign prostate hyperplasia patients:a case-control study[J]. BMC Cancer, 2011, 11:53.
[37] 刘斌波. 猪鼻支原体抗原在人结肠腺癌细胞表达的研究[D]. 南宁:广西大学, 1999.
LIU B B. Expression of Mycoplasma hyorhinis antigens expressing in human colon adenocarcinoma cells[D]. Nanning:Guangxi University, 1999. (in Chinese)
[38] 马华崇, 马泓, 张艳丽, 等. 胃癌组织中猪鼻支原体的分离培养与鉴定[J]. 中国人兽共患病杂志, 2003, 19(2):31-33.
MA H C, MA H, ZHANG Y L, et al. Detection and confirmation of Mycoplasma hyorhinis in gastric carcinoma specimens by culture and PCR[J]. Chinese Journal of Zoonoses, 2003, 19(2):31-33. (in Chinese)
[39] 厉建蕾, 施嘉骏, 李泉, 等. 猪鼻支原体(Mycoplasma hyorhinis)诱导NCI-H446等小细胞肺癌细胞在FIGNL1沉默时出现S期阻滞[J]. 微生物学通报, 2017, 44(2):411-419.
LI J L, SHI J J, LI Q, et al. Mycoplasma hyorhinis induces S phase arrest when suppressing expression of FIGNL1 in NCI-H446 and NCI-H1688 human small cell lung cancer cells[J]. Microbiology China, 2017, 44(2):411-419. (in Chinese)
[40] TSAI S, WEAR D J, SHIH J W, et al. Mycoplasmas and oncogenesis:persistent infection and multistage malignant transformation[J]. Proc Natl Acad Sci U S A, 1995, 92(22):10197-10201.
[41] JIANG S, ZHANG S M, LANGENFELD J, et al. Mycoplasma infection transforms normal lung cells and induces bone morphogenetic protein 2 expression by post-transcriptional mechanisms[J]. J Cell Biochem, 2008, 104(2):580-594.
[42] MUSHABEN E M. BMPR2 and mTOR signaling pathways in inflammatory lung diseases[D]. Cincinnati:University of Cincinnati, 2012.
[43] 徐杰, 赵为民, 任守文, 等. CYP1A1与PPAR-γ在猪肺炎支原体感染炎性反应调控中的作用关系[J]. 畜牧兽医学报, 2016, 47(3):574-580.
XU J, ZHAO W M, REN S W, et al. Interaction effect of CYP1A1 and PPAR-γ in the regulation of inflammation of mycoplasma pneumonia in swine[J]. Acta Veterinaria et Zootechnica Sinica, 2016, 47(3):574-580. (in Chinese)
[44] RELICH R F, BALISH M F. Insights into the function of Mycoplasma pneumoniae protein P30 from orthologous gene replacement[J]. Microbiology, 2011, 157(10):2862-2870.
[45] MIYATA M, HAMAGUCHI T. Integrated information and prospects for gliding mechanism of the pathogenic bacterium Mycoplasma pneumoniae[J]. Front Microbiol, 2016, 7:960.
[46] NAKANE D, ADAN-KUBO J, KENRI T, et al. Isolation and characterization of P1 adhesin, a leg protein of the gliding bacterium Mycoplasma pneumoniae[J]. J Bacteriol, 2011, 193(3):715-722.
[47] MEYER SAUTEUR P M, JACOBS B C, SPUESENS E B M, et al. Antibody responses to Mycoplasma pneumoniae:role in pathogenesis and diagnosis of encephalitis?[J]. PLoS Pathog, 2014, 10(6):e1003983.